張震東 Dr. Geen-Dong Chang

專任教授

  • IBS R403
  • (02)33664071、(02)23665541
  • (02)23635038
  • gdchang@ntu.edu.tw
  • 蛋白質純化、細胞壓力反應

【學歷】

1988

美國伊利諾大學生理及生物物理系 博士

1980

國立臺灣大學 生化科學研究所 碩士

1978

國立臺灣大學 動物系 學士

 

【經歷】

1995-

國立臺灣大學 理學院 生化科學研究所 教授

1989-1995

國立臺灣大學大學生化科學所 副教授

1988-1989

美國伊利諾大學 博士後研究

1982-1984

美國伊利諾大學 助教

 

【研究方向】

  • Cell responses to oxidative stress
  • Target identification of small-molecule drugs
  • Analytical techniques for metabolites by LC-Mass Spectrometry
  • Analytical techniques for protein oxidation modifications


【近年著作】

2019
Lee YJ, Chang GD*. (2019) Quantitative display of the redox status of proteins with maleimide-polyethylene glycol tagging. In press.
2018 Chiu YH, Yang MR, Wang LJ, Chen MH, Chang GD, Chen H. (2018) New insights into the regulation of placental growth factor gene expression by the transcription factors GCM1 and DLX3 in human placenta. J Biol Chem. 2018 Jun 22;293(25):9801-9811.
2018
Yu CH, Chou CC, Tu HF, Huang WC, Ho YY, Khoo KH, Lee MS* and Chang GD*. (2018) Antibody-assisted target identification reveals afatinib, an EGFR covalent inhibitor, down-regulating ribonucleotide reductase. Oncotarget, 9 (30): 21512-21529
2018 Yu CH, Chou CC, Lee DY, Khoo KH, Chang GD*. (2018) Target identification reveals protein arginine methyltransferase 1 is a potential target of phenyl vinyl sulfone and its derivatives. Biosci Rep. 38(2). pii: BSR20171717
2018
Lee DY, Huang WC, Gu TJ, Chang GD*. (2018) Quantitative and comparative liquid chromatography-electrospray ionization-mass spectrometry analyses of hydrogen sulfide and thiol metabolites derivaitized with 2-iodoacetanilide isotopologues. Journal of Chromatography A 1552, 43-52
2018 Kuo CJ, Wang ST, Lin CM, Chiu HC, Huang CR, Lee DY, Chang GD, Chou TC, Chen JW, Chen CS. (2018) A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli. Cell Death Dis. 9(3):381.
2017
Chang CC, Chen CY, Huang CH, Wu CL, Wu HM, Chiu PF, Kor CT, Chen TH, Chang GD, Kuo CC, Wen HC, Huang CY, Chang CH. (2017) Urinary glycated uromodulin in diabetic kidney disease. Clin Sci (Lond). 131(15):1815-1829
2017 Chang CC, Chen CY, Chang GD, Chen TH, Chen WL, Wen HC, Huang CY, Chang CH. (2017) Hyperglycemia and advanced glycation end products (AGEs) suppress the differentiation of 3T3-L1 preadipocytes. Oncotarget. 8(33):55039-55050.
2017 Lin TH, Hsu WH, Tsai PH, Huang YT, Lin CW, Chen KC, Tsai IH, Kandaswami CC, Huang CJ, Chang GD, Lee MT, Cheng CH. (2017) Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling. Food Funct. 8(4):1558-1568
2016 Hsu MF, Pan KT, Chang FY, Khoo KH, Urlaub H, Cheng CF, Chang GD*, Haj FG*, Meng TC*. (2016) S-Nitrosylation of Endogenous Protein Tyrosine Phosphatases in Endothelial Insulin Signaling. Free Radic Biol Med. 99, 199–213
2016 Huang WC, Lee DY, Chang GD*. (2016) Enrichment of metabolite-binding proteins by affinity elution in tandem hydrophobic interaction chromatography (AETHIC) reveals RKIP regulating ERK signaling in an ATP-dependent manner. J Proteome Res. 15, 3574-3584.
2016
Tsai PH, Cheng CH, Lin CY, Huang YT, Lee LT, Kandaswami CC, Lin YC, Lee KP, Hung CC, Hwang JJ, Ke FC, Chang GD*, Lee MT*. (2016) Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells. Anticancer Res. 36, 6367-6380.
2016
Chen IT, Lee DY, Huang YT, Kou GH, Wang HC, Chang GD*, Lo CF*. (2016) Six Hours after Infection, the Metabolic Changes Induced by WSSV Neutralize the Host's Oxidative Stress Defenses. Sci Rep. 2016 6:27732. doi: 10.1038/srep27732

2015

Lin SJ, Lee DY, Wang HC, Kang ST, Hwang PP, Kou GH, Huang MF, Chang GD*, Lo CF*. (2015) White Spot Syndrome Virus Protein Kinase 1 (PK1) Defeats the Host Cell's Iron Withholding Defense Mechanism by Interacting with Host Ferritin. J. Virol. 89, 1083-1093

2015

Lee, DY and Chang GD* (2015), Post-staining electroblotting for reliable peptide blotting, Methods Mol. Biol. 1312:185-195

2015

Lee, DY and Chang GD* (2015), Simultaneous Immunoblotting Analysis with Activity Gel Electrophoresis and 2-D Gel Electrophoresis, Methods Mol. Biol. 1312:61-72

2015

Yu, C.H., Chou, C.C., Lee, Y.J., Khoo, K.Y., and Chang GD*. (2015) Uncovering Protein Polyamination by the Spermine-specific Antiserum and Mass Spectrometric Analysis, Amino Acids, 47, 469–481

2015

Lee, D.Y. and Chang GD* (2015), Quantitative LC-ESI-MS analysis of amine-containing metabolites derivatized with cyanuric chloride and methylamine isotopologues, J. Chromatography A, 1338, 60-68

2014

Su MA, Huang YT, Chen IT, Lee DY, Hsieh YC, Li CY, Ng TH, Liang SY, Lin SY, Huang SW, Chiang YA, Yu HT, Khoo KH, Chang GD, Lo CF, Wang HC. (2014) An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway. PLoS Pathog. 12;10(6):e1004196.

2014

Lee, DY and Chang GD* (2014), Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1, Redox Biology, 2, 196-205

2012

Ho WH, Lee DY, Chang GD*. (2012) Proteomic Identification of a Novel Hsp90-Containing Protein-Mineral Complex Which Can Be Induced in Cells in Response to Massive Calcium Influx, J Proteome Res. 11, 3160−3174.

2012

Huang JY, Liu WJ, Wang HC, Lee DY, Leu JH, Wang HC, Tsai MH, Kang ST, Chen IT, Kou GH, Chang GD*, Lo CF*. (2012) Penaeus monodon thioredoxin restores the DNA binding activity of oxidized white spot syndrome virus IE1, Antioxid Redox Signal., 17, 914-926.

2011

Lin, F.Y., Chang, C.W., Cheong, M.L., Chen, H.C., Lee, D.Y., Chang, G.D*., Chen, H*. ( 2011 ) Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation, Nucleic Acids Res., 39(3), 848-61.

2010

Huang, H.R., Chen, Z.J., Kunes, S., Chang, G.D., and Maniatis, T. ( 2010 ) Endocytic pathway is required for Drosophila Toll innate immune signaling, ProcNatl. Acad. Sci. USA. 107, 8322-8327.

2009

Lee, D.Y. and Chang G.D. ( 2009 ) Electrolytic reduction: modification of proteins occurring in isoelectric focusing electrophoresis and in electrolytic reactions in the presence of high salts, Anal. Chem., 81, 3957-3964.

2009

Lee, D.Y. and Chang G.D. ( 2009 ) Simultaneous immunoblotting analysis with activity gel electrophoresis and 2-D gel electrophoresis, Methods Mol. Biol., 536, 23-33.

2004

Tsai, P.L., Chen, C.H., Huang, C.J., Chou, C.M. and Chang, G.D. ( 2004 ) Purification and cloning of an endogenous protein inhibitor of carp nephrosin, an astacin metalloproteinase, J. Biol. Chem., 279, 11146-11155.

1997

Hung, C. H., Huang, H. R., Huang, C. J., Huang, F. L. and Chang, G. D. ( 1997 ) Purification and cloning of carp nephrosin, a secreted zinc endopeptidase of the Astacin family, J. Biol. Chem., 272, 13772-13778.

1998

張震東 (1998) 神經細胞的結構, pp 61-83, "心與腦", 徐嘉宏主編, 台北: 心理出版社

1998

張震東 (1998) 神經細胞的生理學, pp 84-106, "心與腦", 徐嘉宏主編, 台北: 心理出版社