蕭超隆 Dr. Chiaolong Hsiao

專任助理教授

【學歷】

2008

Ph.D., Bioinformatics, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.

 

【經歷】

2008-2014

Post Doctoral Associate, NAI Ribo-Evo Center, School of Chemistry and Biochemistry, Georgia Institute of Technology

 

【研究方向】

我的實驗室專注核糖體的逆向工程,並探索核酸分子在生物所扮演的功能與角色。

我們專注於各類核酸分子的研究,及核酸分子與金屬之間的關係。另外,我們使用類病毒粒子包裝各種大小不同的核酸分子,作為癌症免疫療法的應用。實驗室所用的技巧包括,生物資訊學、生物物理化學、合成生物化學、構造生物學、分子生物學、細胞生物學、和大分子結晶學。

(Yin and Yang: reductive and oxidative electron transfer of RNA-Fe complex)

(Ribosomei: Ribosome Interference. Shown is the proposed model, highlighted in red, of theHomo sapiens ribosome mimicry.)

(Metal-mediated Oxidative Damage: the proposed model of anti-oxidative ribozyme, aox-RNA.)

 

【近年著作】

2014

A. S. Petrov, C. R. Bernier, C. Hsiao, A. M. Norris, N. A. Kovacs, C. C. Waterbury, V. G. Stepanov, S. C. Harvey, G. E. Fox, R. M. Wartell, N. V. Hud and L. D. Williams. (2014- Jul) Evolution of the ribosome at atomic resolution. Proc Natl Acad Sci U S A111, 10251-10256.

2014

A. S. Petrov, C. R. Bernier, B. Gulen, C. C. Waterbury, E. Hershkovits, C. Hsiao, S. C. Harvey, N. V. Hud, G. E. Fox, R. M. Wartell and L. D. Williams. (2014- Feb) Secondary Structures of rRNAs from All Three Domains of Life. PLoS One9, e88222.

2014

C. Bernier, A. S. Petrov, C. Waterbury, J. Jett, F. Li, L. E. Freil, b. Xiong, L. Wang, A. Le, B. L. Milhouse, E. Hershkovitz, M. Grover, Y. Xue, C. Hsiao, J. C. Bowman, S. C. Harvey, J. Z. Wartel and L. D. Williams. (2014-) Ribovision: Visualization and Analysis of Ribosomes. Discussions of the Faraday Society, Faraday Discuss 169, 195-207 (2014).

2013

Petrov, A.S., Bernier, C.R., Hershkovits, E., Xue, Y., Waterbury, C.C., Hsiao, C., Stepanov, V.G., Gaucher, E.A., Grover, M.A., Harvey, S.C., Hud, N.V., Wartell, R.M., Fox, G.E., Williams, L.D. “Secondary structure and domain architecture of the 23S and 5S rRNAs.” Nucleic Acids Res., 41(15), 7522-7535 (2013).

2013

Hsiao, C., Chou, I.C., Okafor, C.D., Bowman, J.C., O'Neill, E.B., Athavale, S.S., Petrov, A.S., Hud, N.V., Wartell, R.M., Harvey, S.C., Williams, L.D. “RNA with iron(II) as a cofactor catalyses electron transfer.” Nature Chemistry, 5, 525-528 (2013).

2013

Hsiao, C., Lenz, T.K., Peters, J.K., Fang, P.Y., Schneider, D.M., Anderson, E.J., Preeprem, T., Bowman, J.C., O'Neill, E.B., Lie, L., Athavale, S. S., Gossett, J.J., Trippe, C., Murray, J., Petrov, A.S., Wartell, R.M., Harvey, S.C., Hud, N.V., Williams, L.D. “Molecular paleontology: a biochemical model of the ancestral ribosome.”Nucleic Acids Res., 41, 3373-3385 (2013).

2012

Maehigashi T., Hsiao, C., Woods, K.K., Moulaei, T., and Williams, L.D. "DNA Structure is Intrinsically Polymorphic: Even at the level of Watson-Crick Base-Pairs.” Nucleic Acids Res.8, 3714-3722 (2012).

2012

Athavale, S.S., Petrov, A.S., Hsiao, C., Watkins, D., Prickett, C.D., Gossett, J.J., Lie, L., Bowman, J.C., O'Neill, E., Bernier, C.R., Hud, N.V., Wartell, R., Harvey, S.C., and Williams, L.D. "RNA Folding and Catalysis Mediated by Iron (II)", PLoS ONE7(5), e38024 (2012)

2012

Athavale, S.S., Gossett, J.J., Hsiao, C., Bowman, J.C., O'Neill, E., Hershkovitz, E., Preeprem, T., Hud, N.V., Wartell, R.M., Harvey, S.C., and Williams, L.D. "Domain III of the T. thermophilus 23S rRNA Folds Independently to a near-Native State", RNA 18, 752-758 (2012).

2012

Petrov, A.S., Bernier, C., Hsiao, C.; Okafor, C.D., Tannenbaum, E, Stern, J., Gaucher, E., Schneider, D., Hud, N.V, Harvey, S.C.; Williams, L.D., “RNA-Magnesium-Protein Interactions in Large Ribosomal Subunit”, J. Phys. Chem. B116, 8113-8120 (2012).

2010

Mohan, S., Hsiao, C., Bowman, J.C., Wartell, R, and Williams, L.D. "RNA Tetraloop Folding Reveals Tension between Backbone Restraints and Molecular Interactions.”, J. Am. Chem. Soc. 132, 12679-12689 (2010)

2009

Hsiao, C., Mohan, S., B. K. Kalahar, and Williams, L. D. "Peeling the Onion: Ribosomes are Ancient Molecular Fossils", Molecular Biology and Evolution26, 2415-2425 (2009)

2009

Hsiao, C. and Williams, L.D. "A Recurrent Magnesium-Binding Motif Provides a Framework for the Ribosomal Peptidyl Transferase Center", Nucleic Acids Res.37, 3134-3142 (2009)

2009

Mohan S, Hsiao, C., Van Deusen, H., Gallagher, R., Krohn, E., Kalahar, B., Wartell, M.R., Williams, L. D.Mechanism of RNA Double Helix-Propagation at Atomic Resolution”, J. Phys. Chem. B113(9), 2614-2623 (2009)

2009

Apostolico, A., Ciriello, G., Guerra, C., C.E, H., Hsiao, C., and Williams, L. D. "Finding 3D Motifs in Ribosomal RNA Structures", Nucleic Acids Res.37(4):e29 (2009)

2008

Hsiao, C., Tannenbaum, E., Van Deusen, H., Hershkovitz, E., Perng, G., Tannenbaumc, A.R., Williams, L. D., (2008) “Complexes of Nucleic Acids with Group I and II Cations”, Nucleic Acids—Metal Ion Interactions. (Hud, N.V. ed). pp 1-38, Published by Royal Society of Chemistry

2008

Watkins, D., Hsiao, C., Woods, K. K., Koudelka, G. B., and Williams, L. D., "P22 c2 Repressor-Operator Complex: Mechanisms of Direct and Indirect Readout", Biochemistry47, 2325-2338 (2008)

2006

Hsiao, C., Mohan, S., Hershkovitz, E., Tannenbaum, A., Williams, L. D., "Single Nucleotide RNA Choreography", Nucleic Acids Res. 34, 1481-1491 (2006)

2002

Huang, S.T., Kuo, H.S., Hsiao, C., Lin, Y.L. “Efficient Synthesis of ‘Redox-Switched’ Napthoquinone Thio-Crown Ethers and Their Biological Activity Evaluation”, Bioorg. Med. Chem. 10, 1947-1952 (2002)

1996

Lin, M.S., HsiaoC., Kuo, H.S. “Heteroquinones with Biological Activities: Synthesis and Anti-Microbial Activities of 6-Alkylmercapto-7-amino- and 6-amino-7-alkylmercapto-5,8-quinolinequinones”, J. Taipei Medical College25, 12-21 (1996)