【學歷】
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2008 |
Ph.D., Bioinformatics, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA. |
【經歷】
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2008-2014 |
Post Doctoral Associate, NAI Ribo-Evo Center, School of Chemistry and Biochemistry, Georgia Institute of Technology |
【研究方向】
我的實驗室專注核糖體的逆向工程，並探索核酸分子在生物所扮演的功能與角色。
我們專注於各類核酸分子的研究，及核酸分子與金屬之間的關係。另外，我們使用類病毒粒子包裝各種大小不同的核酸分子，作為癌症免疫療法的應用。實驗室所用的技巧包括，生物資訊學、生物物理化學、合成生物化學、構造生物學、分子生物學、細胞生物學、和大分子結晶學。
(Yin and Yang: reductive and oxidative electron transfer of RNA-Fe complex)
(Ribosomei: Ribosome Interference. Shown is the proposed model, highlighted in red, of theHomo sapiens ribosome mimicry.)
(Metal-mediated Oxidative Damage: the proposed model of anti-oxidative ribozyme, aox-RNA.)
【近年著作】
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2014 |
A. S. Petrov, C. R. Bernier, C. Hsiao, A. M. Norris, N. A. Kovacs, C. C. Waterbury, V. G. Stepanov, S. C. Harvey, G. E. Fox, R. M. Wartell, N. V. Hud and L. D. Williams. (2014- Jul) Evolution of the ribosome at atomic resolution. Proc Natl Acad Sci U S A, 111, 10251-10256. |
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2014 |
A. S. Petrov, C. R. Bernier, B. Gulen, C. C. Waterbury, E. Hershkovits, C. Hsiao, S. C. Harvey, N. V. Hud, G. E. Fox, R. M. Wartell and L. D. Williams. (2014- Feb) Secondary Structures of rRNAs from All Three Domains of Life. PLoS One, 9, e88222. |
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2014 |
C. Bernier, A. S. Petrov, C. Waterbury, J. Jett, F. Li, L. E. Freil, b. Xiong, L. Wang, A. Le, B. L. Milhouse, E. Hershkovitz, M. Grover, Y. Xue, C. Hsiao, J. C. Bowman, S. C. Harvey, J. Z. Wartel and L. D. Williams. (2014-) Ribovision: Visualization and Analysis of Ribosomes. Discussions of the Faraday Society, Faraday Discuss 169, 195-207 (2014). |
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2013 |
Petrov, A.S., Bernier, C.R., Hershkovits, E., Xue, Y., Waterbury, C.C., Hsiao, C., Stepanov, V.G., Gaucher, E.A., Grover, M.A., Harvey, S.C., Hud, N.V., Wartell, R.M., Fox, G.E., Williams, L.D. “Secondary structure and domain architecture of the 23S and 5S rRNAs.” Nucleic Acids Res., 41(15), 7522-7535 (2013). |
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2013 |
Hsiao, C., Chou, I.C., Okafor, C.D., Bowman, J.C., O'Neill, E.B., Athavale, S.S., Petrov, A.S., Hud, N.V., Wartell, R.M., Harvey, S.C., Williams, L.D. “RNA with iron(II) as a cofactor catalyses electron transfer.” Nature Chemistry, 5, 525-528 (2013). |
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2013 |
Hsiao, C., Lenz, T.K., Peters, J.K., Fang, P.Y., Schneider, D.M., Anderson, E.J., Preeprem, T., Bowman, J.C., O'Neill, E.B., Lie, L., Athavale, S. S., Gossett, J.J., Trippe, C., Murray, J., Petrov, A.S., Wartell, R.M., Harvey, S.C., Hud, N.V., Williams, L.D. “Molecular paleontology: a biochemical model of the ancestral ribosome.”Nucleic Acids Res., 41, 3373-3385 (2013). |
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2012 |
Maehigashi T., Hsiao, C., Woods, K.K., Moulaei, T., and Williams, L.D. "DNA Structure is Intrinsically Polymorphic: Even at the level of Watson-Crick Base-Pairs.” Nucleic Acids Res., 8, 3714-3722 (2012). |
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2012 |
Athavale, S.S., Petrov, A.S., Hsiao, C., Watkins, D., Prickett, C.D., Gossett, J.J., Lie, L., Bowman, J.C., O'Neill, E., Bernier, C.R., Hud, N.V., Wartell, R., Harvey, S.C., and Williams, L.D. "RNA Folding and Catalysis Mediated by Iron (II)", PLoS ONE, 7(5), e38024 (2012) |
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2012 |
Athavale, S.S., Gossett, J.J., Hsiao, C., Bowman, J.C., O'Neill, E., Hershkovitz, E., Preeprem, T., Hud, N.V., Wartell, R.M., Harvey, S.C., and Williams, L.D. "Domain III of the T. thermophilus 23S rRNA Folds Independently to a near-Native State", RNA 18, 752-758 (2012). |
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2012 |
Petrov, A.S., Bernier, C., Hsiao, C.; Okafor, C.D., Tannenbaum, E, Stern, J., Gaucher, E., Schneider, D., Hud, N.V, Harvey, S.C.; Williams, L.D., “RNA-Magnesium-Protein Interactions in Large Ribosomal Subunit”, J. Phys. Chem. B, 116, 8113-8120 (2012). |
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2010 |
Mohan, S., Hsiao, C., Bowman, J.C., Wartell, R, and Williams, L.D. "RNA Tetraloop Folding Reveals Tension between Backbone Restraints and Molecular Interactions.”, J. Am. Chem. Soc. 132, 12679-12689 (2010) |
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2009 |
Hsiao, C., Mohan, S., B. K. Kalahar, and Williams, L. D. "Peeling the Onion: Ribosomes are Ancient Molecular Fossils", Molecular Biology and Evolution, 26, 2415-2425 (2009) |
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2009 |
Hsiao, C. and Williams, L.D. "A Recurrent Magnesium-Binding Motif Provides a Framework for the Ribosomal Peptidyl Transferase Center", Nucleic Acids Res., 37, 3134-3142 (2009) |
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2009 |
Mohan S, Hsiao, C., Van Deusen, H., Gallagher, R., Krohn, E., Kalahar, B., Wartell, M.R., Williams, L. D.“Mechanism of RNA Double Helix-Propagation at Atomic Resolution”, J. Phys. Chem. B, 113(9), 2614-2623 (2009) |
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2009 |
Apostolico, A., Ciriello, G., Guerra, C., C.E, H., Hsiao, C., and Williams, L. D. "Finding 3D Motifs in Ribosomal RNA Structures", Nucleic Acids Res., 37(4):e29 (2009) |
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2008 |
Hsiao, C., Tannenbaum, E., Van Deusen, H., Hershkovitz, E., Perng, G., Tannenbaumc, A.R., Williams, L. D., (2008) “Complexes of Nucleic Acids with Group I and II Cations”, Nucleic Acids—Metal Ion Interactions. (Hud, N.V. ed). pp 1-38, Published by Royal Society of Chemistry |
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2008 |
Watkins, D., Hsiao, C., Woods, K. K., Koudelka, G. B., and Williams, L. D., "P22 c2 Repressor-Operator Complex: Mechanisms of Direct and Indirect Readout", Biochemistry, 47, 2325-2338 (2008) |
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2006 |
Hsiao, C., Mohan, S., Hershkovitz, E., Tannenbaum, A., Williams, L. D., "Single Nucleotide RNA Choreography", Nucleic Acids Res. 34, 1481-1491 (2006) |
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2002 |
Huang, S.T., Kuo, H.S., Hsiao, C., Lin, Y.L. “Efficient Synthesis of ‘Redox-Switched’ Napthoquinone Thio-Crown Ethers and Their Biological Activity Evaluation”, Bioorg. Med. Chem. 10, 1947-1952 (2002) |
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1996 |
Lin, M.S., Hsiao, C., Kuo, H.S. “Heteroquinones with Biological Activities: Synthesis and Anti-Microbial Activities of 6-Alkylmercapto-7-amino- and 6-amino-7-alkylmercapto-5,8-quinolinequinones”, J. Taipei Medical College, 25, 12-21 (1996) |
