Dr. Lung-Chih Yu

Name：Dr. Lung-Chih Yu

Title：Faculty

Lab Office：IBS 404、406

Phone：(02)33664070、(02)23665546

Email：yulc@ntu.edu.tw

Research：Molecular Genetics of the Human Red Cell Antigens

Journal Papers

Journal Papers
Book Papers
Degrees and Positions Held
Research

Year	Paper Title
2018	Yeh CC, Chang CJ, Twu YC, Liu BS Huang JT, Hung ST, Chu CC, Chan YS, Tsai YJ, Lin SW, Lin M, Yu LC.* The molecular genetic background leading to formation of the human erythroid-specific Xga/CD99 blood groups. Blood Advances. 2018;2(15):1854–1864.
2018	Yeh CC, Chang CJ, Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, Lin SW, Yu LC.* The differential expression of the blood group P1-A4GALT and P2-A4GALT alleles is stimulated by the transcription factor early growth response 1. Transfusion. 2018; 58(4):1054–1064.
2016	Chen PT, Chen ZT, Hou WC, Yu LC, Chen RP. Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease. Sci Rep. 2016;6:29760.
2014	Lai YJ, Wu WY, Yang CM, Yang LR, Chu CC, Chan YS, Lin M, Yu LC*. A systematic study of SNPs in theA4GALT gene suggests a molecular genetic basis for the P1/P2 blood groups. Transfusion. 2014
2014	Lu CH, Wu WY, Lai YJ, Yang CM, Yu LC*. Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells. Glycobiology. 2014;24(4):359–367.
2011	Yu LC*, Lin M. Molecular genetics of the blood group I system and the regulation of I antigen expression in erythropoiesis and granulopoiesis. Curr Opin Hematol. 2011;18:421–426.
2010	Twu YH, Hsieh CY, Lin M, Tzeng CH, Sun CF, Yu LC*. Phosphorylation status of transcription factor C/EBPα determines cell surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis. Blood. 2010;115:2491–2499.
2008	Wang HR, Hsieh CY, Twu YC, Yu LC*. Expression of human Sda β-1,4-N-acetylgalactosaminyltransferase II gene is dependent on promoter methylation status. Glycobiology. 2008;18:104–113.
2007	Twu YC, Chen CP, Hsieh CY, Tzeng CH, Sun CF, Wang SH, Chang MS, Yu LC*. I branching formation in erythroid differentiation is regulated by transcription factor C/EBPα. Blood. 2007;111:4526–4534.
2003	Yu LC, Twu YC, Chou ML, Reid ME, Gray AR, Moulds JM, Chang CY, Lin M*. The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts. Blood. 2003;101:2081–2088.
2002	Yu LC, Twu YC, Chou ML, Chang CY, Wu CY, Lin M*. Molecular genetic analysis for the B3 allele. Blood. 2002;100:1490–1492.
2001	Yu LC, Twu YC, Chang CY, Lin M*. Molecular basis of the adult i phenotype and the gene responsible for the expression of human blood group I antigen. Blood. 2001;98:3840–3845.

Year	Paper Title
2018	張小琳、余榮熾(2018)。第2章：ABO、H、Lewis血型系統。林媽利（總校閱），輸血醫學[第四版]。臺北：五南。
2018	余榮熾、涂玉青(2018)。第5章：P1PK血型系統與相關抗原/I血型系統與i抗原。林媽利（總校閱），輸血醫學[第四版]。臺北：五南。
	王昌玲、張小琳、余榮熾。第6章：其他血型系統(Kidd、Duffy、Kell、Diego及Lutheran)。林媽利（總校閱），輸血醫學[第四版]。臺北：五南。

School Name	Department	Degree	Period
National Taiwan University College of Life Science	Institute of Biochemical Science	Professor	2008 – present
Academia Sinica	Institute of Biological Chemistry	Joint Appointment Associate Research Fellow	2008 – present
Academia Sinica	Institute of Biological Chemistry	Joint Appointment Assistant Research Fellow	2003 – 2008
National Taiwan University College of Life Science	Institute of Biochemical Science	Associate Professor	2002 – 2008
Mackay Memorial Hospital	Dept. of Medical Research	Investigator	1998 – 2002
Mackay Memorial Hospital	Dept. of Medical Research	Associate Investigator	1993 – 1997
National Taiwan University	Graduate Institute of Biochemical Sciences	Ph.D.	1989 – 1994
National Taiwan University	Graduate Institute of Biochemical Sciences	M.S.	1985 – 1987
National Taiwan University	Department of Zoology	B.S.	1981 – 1985

Molecular Genetics of the Human Red Cell Antigens.

Our laboratory is interested in the molecular genetic bases responsible for the polymorphisms of the human red cell surface antigens; especially interested in the antigens with carbohydrate structure. The research topics that we have implemented during these years include: the ABO blood group glycosyltransferase genes and the rare ABO blood types, Secretor a-1,2-fucosyltransferase gene and the Lewis antigen phenotypes, and the molecular genetics of the I b-1,6-N-acetylglucosaminyltransferase locus and the partial association with congenital cataracts. The expression profiles of the carbohydrate antigens during cell differentiation processes and the regulatory mechanisms of the related glycosyltransferase genes are also our research interests. Currently we endeavor to elucidate the molecular genetic basis for the polymorphism of the P1 (Gala1-4GalNAcb1-3Gal) antigen on red cell surfaces and the expression of I branching carbohydrate structure and the regulatory mechanisms of the I gene transcription during cell differentiation.