Dr. Chiaolong Hsiao

Name：Dr. Chiaolong Hsiao

Title：Full-Time Associate Professor

Lab Office：IBS N402

Phone：(02)33664073、(02)23665582

Email：chiaolong@ntu.edu.tw

Research：Nucleic acid research

Journal Papers

Journal Papers
Books
Degrees and Positions Held
Research

Year	Paper Title
2019	Lin, S.-Y., Wang, Y.-C. & Hsiao, C. Prebiotic Iron Originates the Peptidyl Transfer Origin. Molecular Biology and Evolution 36, 999-1007 (2019).
2019	Chen, J.-K., Hsiao, C., Wu, J.-S., Lin, S.-Y. & Wang, C.-Y. Characterization of the endonuclease activity of the replication-associated protein of beak and feather disease virus. Arch. Virol. 164, 2091-2106 (2019).
2018	Fang, P.-Y., Bowman, J. C., Gomez Ramos, L., Hsiao, C. & Williams, L. D. RNA: packaged and protected by VLPs. RSC Advances 8, 21399-21406 (2018).
2014	A. S. Petrov, C. R. Bernier, C. Hsiao, A. M. Norris, N. A. Kovacs, C. C. Waterbury, V. G. Stepanov, S. C. Harvey, G. E. Fox, R. M. Wartell, N. V. Hud and L. D. Williams. (2014- Jul) Evolution of the ribosome at atomic resolution. Proc Natl Acad Sci U S A, 111, 10251-10256.
2014	A. S. Petrov, C. R. Bernier, B. Gulen, C. C. Waterbury, E. Hershkovits, C. Hsiao, S. C. Harvey, N. V. Hud, G. E. Fox, R. M. Wartell and L. D. Williams. (2014- Feb) Secondary Structures of rRNAs from All Three Domains of Life. PLoS One, 9, e88222.
2014	C. Bernier, A. S. Petrov, C. Waterbury, J. Jett, F. Li, L. E. Freil, b. Xiong, L. Wang, A. Le, B. L. Milhouse, E. Hershkovitz, M. Grover, Y. Xue, C. Hsiao, J. C. Bowman, S. C. Harvey, J. Z. Wartel and L. D. Williams. (2014-) Ribovision: Visualization and Analysis of Ribosomes. Discussions of the Faraday Society, Faraday Discuss 169, 195-207 (2014).
2013	Petrov, A.S., Bernier, C.R., Hershkovits, E., Xue, Y., Waterbury, C.C., Hsiao, C., Stepanov, V.G., Gaucher, E.A., Grover, M.A., Harvey, S.C., Hud, N.V., Wartell, R.M., Fox, G.E., Williams, L.D. “Secondary structure and domain architecture of the 23S and 5S rRNAs.” Nucleic Acids Res., 41(15), 7522-7535 (2013).
2013	Hsiao, C., Chou, I.C., Okafor, C.D., Bowman, J.C., O'Neill, E.B., Athavale, S.S., Petrov, A.S., Hud, N.V., Wartell, R.M., Harvey, S.C., Williams, L.D. “RNA with iron(II) as a cofactor catalyses electron transfer.” Nature Chemistry, 5, 525-528 (2013).
2013	Hsiao, C., Lenz, T.K., Peters, J.K., Fang, P.Y., Schneider, D.M., Anderson, E.J., Preeprem, T., Bowman, J.C., O'Neill, E.B., Lie, L., Athavale, S. S., Gossett, J.J., Trippe, C., Murray, J., Petrov, A.S., Wartell, R.M., Harvey, S.C., Hud, N.V., Williams, L.D. “Molecular paleontology: a biochemical model of the ancestral ribosome.”Nucleic Acids Res., 41, 3373-3385 (2013).
2012	Maehigashi T., Hsiao, C., Woods, K.K., Moulaei, T., and Williams, L.D. "DNA Structure is Intrinsically Polymorphic: Even at the level of Watson-Crick Base-Pairs.” Nucleic Acids Res., 8, 3714-3722 (2012).
2012	Athavale, S.S., Petrov, A.S., Hsiao, C., Watkins, D., Prickett, C.D., Gossett, J.J., Lie, L., Bowman, J.C., O'Neill, E., Bernier, C.R., Hud, N.V., Wartell, R., Harvey, S.C., and Williams, L.D. "RNA Folding and Catalysis Mediated by Iron (II)", PLoS ONE, 7(5), e38024 (2012)
2012	Athavale, S.S., Gossett, J.J., Hsiao, C., Bowman, J.C., O'Neill, E., Hershkovitz, E., Preeprem, T., Hud, N.V., Wartell, R.M., Harvey, S.C., and Williams, L.D. "Domain III of the T. thermophilus 23S rRNA Folds Independently to a near-Native State", RNA 18, 752-758 (2012).
2012	Petrov, A.S., Bernier, C., Hsiao, C.; Okafor, C.D., Tannenbaum, E, Stern, J., Gaucher, E., Schneider, D., Hud, N.V, Harvey, S.C.; Williams, L.D., “RNA-Magnesium-Protein Interactions in Large Ribosomal Subunit”, J. Phys. Chem. B, 116, 8113-8120 (2012).
2010	Mohan, S., Hsiao, C., Bowman, J.C., Wartell, R, and Williams, L.D. "RNA Tetraloop Folding Reveals Tension between Backbone Restraints and Molecular Interactions.”, J. Am. Chem. Soc. 132, 12679-12689 (2010)
2009	Hsiao, C., Mohan, S., B. K. Kalahar, and Williams, L. D. "Peeling the Onion: Ribosomes are Ancient Molecular Fossils", Molecular Biology and Evolution, 26, 2415-2425 (2009)
2009	Hsiao, C. and Williams, L.D. "A Recurrent Magnesium-Binding Motif Provides a Framework for the Ribosomal Peptidyl Transferase Center", Nucleic Acids Res., 37, 3134-3142 (2009)
2009	Mohan S, Hsiao, C., Van Deusen, H., Gallagher, R., Krohn, E., Kalahar, B., Wartell, M.R., Williams, L. D.“Mechanism of RNA Double Helix-Propagation at Atomic Resolution”, J. Phys. Chem. B, 113(9), 2614-2623 (2009)
2009	Apostolico, A., Ciriello, G., Guerra, C., C.E, H., Hsiao, C., and Williams, L. D. "Finding 3D Motifs in Ribosomal RNA Structures", Nucleic Acids Res., 37(4):e29 (2009)
2008	Hsiao, C., Tannenbaum, E., Van Deusen, H., Hershkovitz, E., Perng, G., Tannenbaumc, A.R., Williams, L. D., (2008) “Complexes of Nucleic Acids with Group I and II Cations”, Nucleic Acids—Metal Ion Interactions. (Hud, N.V. ed). pp 1-38, Published by Royal Society of Chemistry
2008	Watkins, D., Hsiao, C., Woods, K. K., Koudelka, G. B., and Williams, L. D., "P22 c2 Repressor-Operator Complex: Mechanisms of Direct and Indirect Readout", Biochemistry, 47, 2325-2338 (2008)
2006	Hsiao, C., Mohan, S., Hershkovitz, E., Tannenbaum, A., Williams, L. D., "Single Nucleotide RNA Choreography", Nucleic Acids Res. 34, 1481-1491 (2006)
2002	Huang, S.T., Kuo, H.S., Hsiao, C., Lin, Y.L. “Efficient Synthesis of ‘Redox-Switched’ Napthoquinone Thio-Crown Ethers and Their Biological Activity Evaluation”, Bioorg. Med. Chem. 10, 1947-1952 (2002)
1996	Lin, M.S., Hsiao, C., Kuo, H.S. “Heteroquinones with Biological Activities: Synthesis and Anti-Microbial Activities of 6-Alkylmercapto-7-amino- and 6-amino-7-alkylmercapto-5,8-quinolinequinones”, J. Taipei Medical College, 25, 12-21 (1996)

Year	Book Title
2017	水書：掀開生命之水新的一章 (Water at the turning point: a new chapter of water in life)，作者：蕭超隆、郭憲壽。2017/1/12出版，出版社：養沛文化。

School Name	Department	Degree	Period
Academia Sinica	Institute of Biological Chemistry	Joint Appointment Associate Research Fellow	2021 – present
National Taiwan University	Institute of Biochemical Sciences	Associate Professor	2019 – present
Academia Sinica	Institute of Biological Chemistry	Joint Appointment Assistant Research Fellow	2015 – 2021
National Taiwan University	Institute of Biochemical Sciences	Assistant Professor	2014 – 2019
Georgia Institute of Technology		Post Doctoral Associate	2008 – 2014
Georgia Institute of Technology, Atlanta, GA, USA.	School of Chemistry and Biochemistry	Ph.D.	2008

The main foci of my lab are to reverse-engineer the ribosomes, and to uncover, discover novel functions of RNA.

We are interested in the RNA research: folding, assembly, and functions, using bioinformatics, biophysical chemistry, synthetic biochemistry, structural biology, molecular biology, and cell biology. We pay extraordinary attentions to the RNA association with metals, beyond group I and group II cations. In addition we use virus-like particle (VLP) to pack various sizes of RNA for cancer immunotherapy.